SEQUENTIAL IMMUNE ACQUISITION OF MONOCLONAL ANTIBODIES ENHANCES PHAGOCYTOSIS OF ACINETOBACTER BAUMANNII BY RECOGNIZING ATP SYNTHASE

Sequential Immune Acquisition of Monoclonal Antibodies Enhances Phagocytosis of Acinetobacter baumannii by Recognizing ATP Synthase

Objectives: The aim of this study was to prepare monoclonal antibodies (mAbs) that broadly target Acinetobacter baumannii and protect against infection by multi-drug-resistant (MDR) A.baumannii from different sources.Methods: mAb 8E6 and mAb 1B5 were prepared by sequentially immunizing mice with a sublethal inoculation of three heterogeneous seroty

read more


Mechanisms regulating the CRISPR-Cas systems

The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats- CRISPR associated proteins) is a prokaryotic system that enables sequence specific recognition and cleavage of nucleic acids.This is possible due to cooperation between CRISPR array which contains short fragments of DNA called spacers that are complimentary to the targeted n

read more